Dosage:
Tablet: 1 tablet as single initial dose, followed by 1 tablet after 8 hours and then 1 tablet twice a day for the following two days.
Suspension: The dose depends on the severity of the case and the clinical situation of the payment. In general, 4mg Artemeter/kg body weight in combination with a 6 fold of that dos for Lumefantrine per day, administered as single dose.
Best Features:
- Latest Fixed Dose – Artemether based combination Therapy (ACT) recommended by WHO.
- Excellent safety, tolerability and efficacy with minimal side effects and treatment failure
- Indicactions:
- All types of malaria including falciparum
- Chloroquinine resistant malaria
- Several malaria
- Cerebral malaria
Rationale of Combination
- Shorter fever and parasite clearance times than other antimalarial drugs
- Significant lowered gametocyte carriage as the treatment with this combination therapy proceeds
- Selective toxicity and least probability of resistance development by various malarial strains especially P. falciparum
- The antimalarial activity of the combination of Lumefantrine and Atemether is highly acceptable with 95% cute rate against falciparum malaria.
- Artemether rapidly reduces parasite biomass and quickly resolve clinical symptoms, while the long action of Lumefantrine is thought to prevent recrudescence.
- Artemether is fast acting drug with short half life and lumefantrine acts slowly with longer half Life.
